A Rare Case of Familial Reactive Perforating Collagenosis
نویسندگان
چکیده
A 4 year old boy presented with history of itchy raised lesions on body of 2 years duration. Though parental consanguinity was not present, his elder brother had similar complaints. Dermatological examination revealed multiple hyperpigmented papules with a central keratotic plug distributed mainly over face and extensors of upper and lower extremities. Koebnerisation was present. Skin biopsy revealed perforating collagen bundles in the upper dermis and epidermis which was confirmed by Van Gieson staining. Patient was being treated with topical retinoids and intralesional corticosteroids with minimal relief.
منابع مشابه
Giant acquired reactive perforating collagenosis in a patient with diabetes mellitus and metastatic breast carcinoma.
ARPC: acquired reactive perforating collagenosis RPC: reactive perforating collagenosis INTRODUCTION Acquired reactive perforating collagenosis (ARPC) is a type of perforating disorder that is often associated with underlying systemic diseases, such as diabetes mellitus, renal failure, or malignancy. Giant variants of ARPC may reach up to 2 cm in size and have been reported in only a handful of...
متن کاملAllopurinol in the treatment of acquired reactive perforating collagenosis*
Acquired reactive perforating collagenosis is a perforating dermatosis usually associated with different systemic diseases, mainly diabetes mellitus and/or chronic renal insufficiency. Different therapies have been tried but treatment is not standardized yet and remains a challenge. In the last few years, allopurinol has been reported as a good therapeutic option for acquired reactive perforati...
متن کاملTacalcitol in the Treatment of Acquired Perforating Collagenosis
Acquired perforating collagenosis (APC) is a rare perforating dermatosis characterized by transepidermal collagen elimination. We describe a 65-year-old patient, with long-standing type 2 diabetes mellitus and a 2-year history of itchy hyperkeratotic nodules situated on the back, who was subsequently diagnosed with APC. Treatment included topical corticosteroids and antihistamines, without impr...
متن کاملAcquired reactive perforating collagenosis.
Acquired reactive perforating collagenosis (ARPC) is commonly recognized as an unusual skin reaction to superficial trauma that is observed in patients with a certain genetic predisposition or underlying diseases, such as diabetes mellitus or renal diseases. We present the unusual case of a 55-year-old female diabetic patient with numerous characteristic dome-shaped nodules, which consisted of ...
متن کاملAcquired reactive perforating collagenosis in association with pulmonary papillary adenocarcinoma
Reactive perforating collagenosis is one of the perforatingdermatoses; the acquired form is characterized by transepithelialelimination of altered collagen bundles. It has been seen inassociation with multiple disorders including diabetes mellitus,renal failure, hyperparathyroidism, liver disease, neurodermatitis,IgA nephropathy, and periampullary carcinoma with jaundice.According to the litera...
متن کاملKyrle Disease and Acquired Perforating Collagenosis Secondary to Chronic Renal Failure and Diabetes Mellitus
A 59-year-old man with chronic renal failure and diabetes mellitus presented with pruritic crusted lesions which histologically were perforating disorders, showing features of both Kyrle disease and acquired perforating collagenosis. The mechanisms of transepidermal elimination and the classification of perforating disorders are briefly discussed. Additionally, we question the concept of perfor...
متن کامل